Molecular engineering of cell therapies

Cellular therapies offer an exciting prospect for treatment of cancer and other diseases. Achieving more effective cellular therapies requires exquisite control of the functional, disease-fighting state. How do we engineer cells to maintain a functional state in the body? What special capabilities can we program into cells to give them extra disease-fighting powers? We develop new molecular interventions to improve control and performance of immune cell therapies. To develop these new enhancements for engineered cell therapies, we use approaches from protein engineering and design, mammalian synthetic biology, and immune cell engineering.